Top Cited Papers (WoS Core)
类泛素化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#1626 引用
NATURE CELL BIOLOGY · 2008 · Vol.10 (5) · p.547-555
Lallemand-Breitenbach, V; Jeanne, M; Benhenda, S; Nasr, R; et al.
In acute promyelocytic leukaemia (APL), arsenic trioxide induces degradation of the fusion protein encoded by the PML-RARA oncogene, differentiation of leukaemic cells and produces clinical remissions. SUMOylation of its PML moiety was previously implicated, but the nature of the…
#2194 引用
JOURNAL OF GENETICS AND GENOMICS · 2017 · Vol.44 (5) · p.243-250
Xu, HD; Zhou, JQ; Lin, SF; Deng, WK; et al.
Post-translational modifications (PTMs) occurring at protein lysine residues, or protein lysine modifications (PLMs), play critical roles in regulating biological processes. Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here …
#3176 引用
OPEN BIOLOGY · 2017 · Vol.7 (10)
Yang, YF; He, Y; Wang, XX; Liang, ZW; et al.
SUMOylation, as a post-translational modification, plays essential roles in various biological functions including cell growth, migration, cellular responses to stress and tumorigenesis. The imbalance of SUMOylation and deSUMOylation has been associated with the occurrence and pr…
#4132 引用
SCIENCE ADVANCES · 2020 · Vol.6 (11)
Yu, HJ; Bu, C; Liu, YC; Gong, TY; et al.
Previously, we reported that chromodomain Y-like (CDYL) acts as a crotonyl-coenzyme A hydratase and negatively regulates histone crotonylation (Kcr). However, the global CDYL-regulated crotonylome remains unclear. Here, we report a large-scale proteomics analysis for protein Kcr.…
#597 引用
BRIEFINGS IN BIOINFORMATICS · 2019 · Vol.20 (6) · p.2267-2290
Chen, Z; Liu, XH; Li, FY; Li, C; et al.
Lysine post-translational modifications (PTMs) play a crucial role in regulating diverse functions and biological processes of proteins. However, because of the large volumes of sequencing data generated from genome-sequencing projects, systematic identification of different type…
#674 引用
OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY · 2017 · Vol.21 (5) · p.245-256
Brohi, RD; Huo, LJ
Spermatogenesis is a complex and highly regulated process. The ability of spermatozoa to perform its function depends on multiple physiological and genetic factors that are not fully understood. Notably, due to lack of transcriptional and translational activity in spermatozoa, po…
#771 引用
CELL DEATH DISCOVERY · 2023 · Vol.9 (1)
Cheng, XL; Wang, K; Zhao, Y; Wang, K
Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling, myocardial ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among the greatest threats to human health worldwide. Cardiovascular pathogenesis has been studied for decades, and…
#866 引用
MODERN PROTEOMICS - SAMPLE PREPARATION, ANALYSIS AND PRACTICAL APPLICATIONS · 2016 · Vol.919 · p.345-382
Ke, M; Shen, HA; Wang, LJ; Luo, SS; et al.
Posttranslational modifications (PTMs) are important biochemical processes for regulating various signaling pathways and determining specific cell fate. Mass spectrometry (MS)-based proteomics has been developed extensively in the past decade and is becoming the standard approach…
#962 引用
JOURNAL OF PROTEOME RESEARCH · 2012 · Vol.11 (5) · p.2625-2634
Xu, YM; Huang, DY; Chiu, JF; Lau, ATY
Heat shock factors (HSFs) are vital for modulating stress and heat shock-related gene expression in cells. The activity of HSFs is controlled largely by post-translational modifications (PTMs). For example, basal phosphorylation of HSF1 on three serine sites suppresses the heat s…
#1061 引用
JOURNAL OF PROTEOME RESEARCH · 2012 · Vol.11 (2) · p.1108-1117
Yang, W; Thompson, JW; Wang, ZF; Wang, LL; et al.
Transient cerebral ischemia dramatically activates small ubiquitin-like modifier (SUMO2/3) conjugation. In cells exposed to 6 h of transient oxygen/glucose deprivation (OGD), a model of ischemia, SUMOylation increases profoundly between 0 and 30 min following re-oxygenation. To e…