Top Cited Papers (WoS Core)
丙二酰化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#11185 引用
SCIENCE · 2011 · Vol.334 (6057) · p.806-809
Du, JT; Zhou, YY; Su, XY; Yu, JJ; et al.
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectable or very weak deacetyl…
#2194 引用
JOURNAL OF GENETICS AND GENOMICS · 2017 · Vol.44 (5) · p.243-250
Xu, HD; Zhou, JQ; Lin, SF; Deng, WK; et al.
Post-translational modifications (PTMs) occurring at protein lysine residues, or protein lysine modifications (PLMs), play critical roles in regulating biological processes. Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here …
#3190 引用
SIGNAL TRANSDUCTION AND TARGETED THERAPY · 2022 · Vol.7 (1)
Shang, S; Liu, J; Hua, F
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the progress of metabonomics and proteomics, metabolites have been found to affect protein acylations through pr…
#4190 引用
SIGNAL TRANSDUCTION AND TARGETED THERAPY · 2022 · Vol.7 (1)
Shang, S; Liu, J; Hua, F
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the progress of metabonomics and proteomics, metabolites have been found to affect protein acylations through pr…
#5190 引用
SIGNAL TRANSDUCTION AND TARGETED THERAPY · 2022 · Vol.7 (1)
Shang, S; Liu, J; Hua, F
Metabolic reprogramming is involved in the pathogenesis of not only cancers but also neurodegenerative diseases, cardiovascular diseases, and infectious diseases. With the progress of metabonomics and proteomics, metabolites have been found to affect protein acylations through pr…
#6147 引用
CELL REPORTS · 2018 · Vol.22 (6) · p.1365-1373
Kurmi, K; Hitosugi, S; Wiese, EK; Boakye-Agyeman, F; et al.
Lysine succinylation was recently identified as a post-translational modification in cells. However, the molecular mechanism underlying lysine succinylation remains unclear. Here, we show that carnitine palmitoyltransferase 1A (CPT1A) has lysine succinyltransferase (LSTase) activ…
#7116 引用
BRIEFINGS IN BIOINFORMATICS · 2021 · Vol.22 (4)
Lv, H; Dao, FY; Guan, ZX; Yang, H; et al.
As a newly discovered protein posttranslational modification, histone lysine crotonylation (Kcr) involved in cellular regulation and human diseases. Various proteomics technologies have been developed to detect Kcr sites. However, experimental approaches for identifying Kcr sites…
#883 引用
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA · 2017 · Vol.114 (33) · p.8782-8787
Huang, J; Luo, ZQ; Ying, WT; Cao, QC; et al.
New types of modifications of histones keep emerging. Recently, histone H4K8 2-hydroxyisobutyrylation (H4K8(hib)) was identified as an evolutionarily conserved modification. However, how this modification is regulated within a cell is still elusive, and the enzymes adding and rem…
#976 引用
SCIENCE ADVANCES · 2019 · Vol.5 (7)
Dong, HY; Zhai, GJ; Chen, C; Bai, X; et al.
Lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to be an evolutionarily conserved histone mark. Here, we report that CobB serves as a lysine de-2-hydroxyisobutyrylation enzyme that regulates glycolysis and cell growth in prokaryotes. We identified the specific bind…
#1072 引用
JOURNAL OF PROTEOME RESEARCH · 2016 · Vol.15 (6) · p.2060-2071
Qian, LL; Nie, LT; Chen, M; Liu, P; et al.
Protein lysine malonylation is a recently identified post-translational modification (PTM), which is evolutionarily conserved from bacteria to mammals. Although analysis of lysine malonylome in mammalians suggested that this modification was related to energy metabolism, the subs…