Top Cited Papers (WoS Core)
甲基化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#11510 引用
CELL · 2011 · Vol.146 (6) · p.1015-1027
Tan, MJ; Luo, H; Lee, S; Jin, FL; et al.
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved hist…
#2505 引用
MOLECULAR & CELLULAR PROTEOMICS · 2012 · Vol.11 (5) · p.100-107
Xie, ZY; Dai, JBA; Dai, LZ; Tan, MJ; et al.
Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified b…
#3220 引用
JOURNAL OF PINEAL RESEARCH · 2016 · Vol.61 (4) · p.457-469
Xu, W; Cai, SY; Zhang, Y; Wang, Y; et al.
Melatonin is a pleiotropic signaling molecule that provides physiological protection against diverse environmental stresses in plants. Nonetheless, the mechanisms for melatonin-mediated thermotolerance remain largely unknown. Here, we report that endogenous melatonin levels incre…
#4179 引用
NATURE METHODS · 2018 · Vol.15 (3) · p.213-+
Bao, XC; Guo, XP; Yin, MH; Tariq, M; et al.
We combine the labeling of newly transcribed RNAs with 5-ethynyluridine with the characterization of bound proteins. This approach, named capture of the newly transcribed RNA interactome using click chemistry (RICK), systematically captures proteins bound to a wide range of RNAs,…
#5151 引用
DRUG RESISTANCE UPDATES · 2024 · Vol.73
Ou, XQ; Tan, YR; Xie, JD; Yuan, JP; et al.
Aims: This study aims to explore the function and mechanism of G Protein -coupled receptor class C group 5 member A (GPRC5A) in docetaxel-resistance and liver metastasis of breast cancer. Methods: Single -cell RNA transcriptomic analysis and bioinformatic analysis are used to scr…
#6115 引用
EBIOMEDICINE · 2020 · Vol.59
Zhou, CL; Zhang, ZC; Zhu, XS; Qian, GW; et al.
Background: Metastasis is the leading cause of death in patients with osteosarcoma. Some of these patients fail to respond to chemotherapy and die of metastasis within a short period. Therefore, it is important to identify novel biomarkers to improve the diagnosis and treatment o…
#784 引用
MOLECULAR & CELLULAR PROTEOMICS · 2017 · Vol.16 (7) · p.1324-1334
Nie, LT; Shuai, L; Zhu, MR; Liu, P; et al.
Type 2 diabetes (T2D) is a major chronic healthcare concern worldwide. Emerging evidence suggests that a histone- modification-mediated epigenetic mechanism underlies T2D. Nevertheless, the dynamics of histone marks in T2D have not yet been carefully analyzed. Using a mass spectr…
#873 引用
CLINICAL AND TRANSLATIONAL MEDICINE · 2021 · Vol.11 (3)
Bian, XY; Shi, DM; Xing, KL; Zhou, HX; et al.
Background S-adenosylmethionine decarboxylase proenzyme (AMD1) is a key enzyme involved in the synthesis of spermine (SPM) and spermidine (SPD), which are associated with multifarious cellular processes. It is also found to be an oncogene in multiple cancers and a potential targe…
#971 引用
CELL DEATH DISCOVERY · 2023 · Vol.9 (1)
Cheng, XL; Wang, K; Zhao, Y; Wang, K
Cardiovascular diseases (CVDs) such as atherosclerosis, myocardial remodeling, myocardial ischemia-reperfusion (I/R) injury, heart failure, and oxidative stress are among the greatest threats to human health worldwide. Cardiovascular pathogenesis has been studied for decades, and…
#1066 引用
MODERN PROTEOMICS - SAMPLE PREPARATION, ANALYSIS AND PRACTICAL APPLICATIONS · 2016 · Vol.919 · p.345-382
Ke, M; Shen, HA; Wang, LJ; Luo, SS; et al.
Posttranslational modifications (PTMs) are important biochemical processes for regulating various signaling pathways and determining specific cell fate. Mass spectrometry (MS)-based proteomics has been developed extensively in the past decade and is becoming the standard approach…