豆蔻酰化蛋白质组学文献
N-Myristoylation — Top Publications

不可逆脂质修饰 (CoA 介导),介导膜定位和蛋白-蛋白互作。NMT 是抗真菌药物靶点。

51WoS 命中论文
10Top 高被引
82最高被引次数
2012–2026覆盖年份
Modification Facts

豆蔻酰化修饰基础

+210.198 Da质谱质量偏移
N-term Gly主要修饰位点
51WoS 收录论文
15 年研究跨度

不可逆脂质修饰 (CoA 介导),介导膜定位和蛋白-蛋白互作。NMT 是抗真菌药物靶点。

Top Cited Papers (WoS Core)

豆蔻酰化 Top 10 高被引论文

按 WoS Core Collection 总被引次数排序,覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。

#182 引用 NATURE CHEMICAL BIOLOGY · 2018 · Vol.14 (7) · p.671-+

Structural and genomic decoding of human and plant myristoylomes reveals a definitive recognition pattern

Castrec, B; Dian, C; Ciccone, S; Ebert, CL; et al.
An organism's entire protein modification repertoire has yet to be comprehensively mapped. N-myristoylation (MYR) is a crucial eukaryotic N-terminal protein modification. Here we mapped complete Homo sapiens and Arabidopsis thaliana myristoylomes. The crystal structures of human …
#248 引用 NATURE PROTOCOLS · 2021 · Vol.16 (11) · p.5083-5122

Proteome-wide analysis of protein lipidation using chemical probes: in-gel fluorescence visualization, identification and quantification of N-myristoylation, N- and S-acylation, O-cholesterylation, S-farnesylation and S-geranylgeranylation

Kallemeijn, WW; Lanyon-Hogg, T; Panyain, N; Grocin, AG; et al.
Protein lipidation is challenging to analyze on the proteome level. This protocol describes metabolic incorporation of lipid probes and their capture via click chemistry, allowing in-gel fluorescence visualization or mass spectrometry analysis. Protein lipidation is one of the mo…
#347 引用 NATURE COMMUNICATIONS · 2021 · Vol.12 (1)

Saturated free fatty acids and association with memory formation

Wallis, TP; Venkatesh, BG; Narayana, VK; Kvaskoff, D; et al.
Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise…
#447 引用 NATURE COMMUNICATIONS · 2021 · Vol.12 (1)

Saturated free fatty acids and association with memory formation

Wallis, TP; Venkatesh, BG; Narayana, VK; Kvaskoff, D; et al.
Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise…
#547 引用 NATURE COMMUNICATIONS · 2021 · Vol.12 (1)

Saturated free fatty acids and association with memory formation

Wallis, TP; Venkatesh, BG; Narayana, VK; Kvaskoff, D; et al.
Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise…
#639 引用 JOURNAL OF PROTEOMICS · 2012 · Vol.75 (3) · p.845-856

Comparative proteomic analysis reveals the mechanisms governing cotton fiber differentiation and initiation

Liu, K; Han, ML; Zhang, CJ; Yao, LY; et al.
Cotton fibers are single-celled seed trichomes and provide an ideal model for studying plant cell patterning. At present, the molecular mechanisms of fiber differentiation and initiation are unclear. To determine the proteins involved in these processes, a comparative proteomic a…
#725 引用 ELIFE · 2020 · Vol.9

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

Broncel, M; Dominicus, C; Vigetti, L; Nofal, SD; et al.
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens. Myristoylation often primes for subsequent palmitoylation and stable membrane attachment, however,…
#824 引用 PARASITOLOGY · 2018 · Vol.145 (2) · p.157-174

New developments in probing and targeting protein acylation in malaria, leishmaniasis and African sleeping sickness

Ritzefeld, M; Wright, MH; Tate, EW
Infections by protozoan parasites, such as Plasmodium falciparum or Leishmania donovani, have a significant health, social and economic impact and threaten billions of people living in tropical and sub-tropical regions of developing countries worldwide. The increasing range of pa…
#921 引用 JOURNAL OF ALZHEIMERS DISEASE · 2016 · Vol.53 (3) · p.875-892

Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models

Bamji-Mirza, M; Li, Y; Najem, D; Liu, QY; et al.
Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-beta (A beta) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD). The minor alleles at two ABCA7 single-nucleotide polymorphisms (SNPs), rs3764650 (…
#1021 引用 FRONTIERS IN PLANT SCIENCE · 2022 · Vol.13

Protein S-acyltransferases and acyl protein thioesterases, regulation executors of protein S-acylation in plants

Li, JC; Zhang, MQ; Zhou, LJ
Protein S-acylation, also known as palmitoylation, is an important lipid post-translational modification of proteins in eukaryotes. S-acylation plays critical roles in a variety of protein functions involved in plant development and responses to abiotic and biotic stresses. The s…
Year Trend

豆蔻酰化研究年度发表趋势

下图展示该修饰在 WoS 收录论文中的年度分布。柱高为当年命中数,反映该修饰的研究热度变化。

2002 - 2026 WoS 收录该修饰相关论文趋势(本库共 51 篇覆盖本修饰关键词)

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