Top Cited Papers (WoS Core)
磷酸化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#11510 引用
CELL · 2011 · Vol.146 (6) · p.1015-1027
Tan, MJ; Luo, H; Lee, S; Jin, FL; et al.
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved hist…
#2644 引用
MOLECULAR & CELLULAR PROTEOMICS · 2011 · Vol.10 (12)
Peng, C; Lu, ZK; Xie, ZY; Cheng, ZY; et al.
Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key role in the regulation of diverse cellular physiology. Here we report discovery of a new type of…
#3342 引用
NATURE PROTOCOLS · 2013 · Vol.8 (3) · p.461-480
Zhou, HJ; Ye, ML; Dong, J; Corradini, E; et al.
Mass spectrometry (MS)-based proteomics has become the preferred tool for the analysis of protein phosphorylation. To be successful at such an endeavor, there is a requirement for an efficient enrichment of phosphopeptides. This is necessary because of the substoichiometric natur…
#4292 引用
ACS NANO · 2012 · Vol.6 (4) · p.3179-3188
Ma, WF; Zhang, Y; Li, LL; You, LJ; et al.
Selective enrichment of phosphoproteins or phosphopeptides from complex mixtures is essential for MS-based phosphoproteomics, but still remains a challenge. In this article, we described an unprecedented approach to synthesize magnetic mesoporous Fe3O4@mTiO(2) microspheres with a…
#5281 引用
AUTOPHAGY · 2015 · Vol.11 (1) · p.28-45
Xie, YC; Kang, R; Sun, XF; Zhong, MZ; et al.
Macroautophagy is an intracellular catabolic process involved in the formation of multiple membrane structures ranging from phagophores to autophagosomes and autolysosomes. Dysfunction of macroautophagy is implicated in both physiological and pathological conditions. To date, 38 …
#6278 引用
CELL REPORTS · 2021 · Vol.37 (5)
He, LZ; Jhong, JH; Chen, Q; Huang, KY; et al.
Macrophages undergoing M1-versus M2-type polarization differ significantly in their cell metabolism and cellular functions. Here, global quantitative time-course proteomics and phosphoproteomics paired with transcriptomics provide a comprehensive characterization of temporal chan…
#7238 引用
JOURNAL OF PROTEOME RESEARCH · 2008 · Vol.7 (9) · p.3957-3967
Zhou, HJ; Ye, ML; Dong, J; Han, GH; et al.
The elucidation of protein post-translational modifications, such as phosphorylation, remains a challenging analytical task for proteomic studies. Since many of the proteins targeted for phosphorylation are low in abundance and phosphorylation is typically substoichiometric, a pr…
#8228 引用
MOLECULAR & CELLULAR PROTEOMICS · 2007 · Vol.6 (9) · p.1656-1665
Feng, S; Ye, ML; Zhou, HJ; Jiang, XG; et al.
Large scale characterization of phosphoproteins requires highly specific methods for purification of phosphopeptides because of the low abundance of phosphoproteins and substoichiometry of phosphorylation. Enrichment of phosphopeptides from complex peptide mixtures by IMAC is a p…
#9228 引用
NUCLEIC ACIDS RESEARCH · 2005 · Vol.33 · p.W184-W187
Xue, Y; Zhou, FF; Zhu, MJ; Ahmed, K; et al.
Protein phosphorylation plays a fundamental role in most of the cellular regulatory pathways. Experimental identification of protein kinases' (PKs) substrates with their phosphorylation sites is laborintensive and often limited by the availability and optimization of enzymatic re…
#10216 引用
JOURNAL OF PROTEOMICS · 2014 · Vol.96 · p.253-262
Bian, YY; Song, CX; Cheng, K; Dong, MM; et al.
Protein phosphorylation is one of the most common post-translational modifications. It plays key roles in regulating diverse biological processes of liver tissues. To better understand the role of protein phosphorylation in liver functions, it is essential to perform in-depth pho…