Top Cited Papers (WoS Core)
巴豆酰化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#1135 引用
JOURNAL OF PROTEOME RESEARCH · 2017 · Vol.16 (4) · p.1743-1752
Wei, W; Mao, AQ; Tang, B; Zeng, QF; et al.
Lysine crotonylation on histones is a recently identified post-translational modification that has been demonstrated to associate with active promoters and to directly stimulate transcription. Given that crotonyl-CoA is essential for the acyl transfer reaction and it is a metabol…
#2119 引用
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE · 2019 · Vol.23 (11) · p.7163-7169
Wan, JH; Liu, HY; Chu, J; Zhang, HQ
Lysine crotonylation is a newly discovered post-translational modification, which is structurally and functionally different from the widely studied lysine acetylation. Recent advances in the identification and quantification of lysine crotonylation by mass spectrometry have reve…
#3116 引用
BRIEFINGS IN BIOINFORMATICS · 2021 · Vol.22 (4)
Lv, H; Dao, FY; Guan, ZX; Yang, H; et al.
As a newly discovered protein posttranslational modification, histone lysine crotonylation (Kcr) involved in cellular regulation and human diseases. Various proteomics technologies have been developed to detect Kcr sites. However, experimental approaches for identifying Kcr sites…
#487 引用
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA · 2024 · Vol.121 (50)
Zhai, GJ; Niu, ZP; Jiang, ZX; Zhao, F; et al.
Lysine lactylation (Kla) is a new type of histone mark implicated in the regulation of various functional processes such as transcription. However, how this histone mark acts in cancers remains unexplored due in part to a lack of knowledge about its reader proteins. Here, we obse…
#586 引用
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH · 2022 · Vol.41 (1)
Fu, YD; Yu, J; Li, F; Ge, SF
Metabolites are intermediate products of cellular metabolism catalysed by various enzymes. Metabolic remodelling, as a biochemical fingerprint of cancer cells, causes abnormal metabolite accumulation. These metabolites mainly generate energy or serve as signal transduction mediat…
#676 引用
SCIENCE ADVANCES · 2019 · Vol.5 (7)
Dong, HY; Zhai, GJ; Chen, C; Bai, X; et al.
Lysine 2-hydroxyisobutyrylation (Khib) has recently been shown to be an evolutionarily conserved histone mark. Here, we report that CobB serves as a lysine de-2-hydroxyisobutyrylation enzyme that regulates glycolysis and cell growth in prokaryotes. We identified the specific bind…
#775 引用
BIOMED RESEARCH INTERNATIONAL · 2021 · Vol.2021
Xu, HW; Wu, MY; Ma, XM; Huang, W; et al.
Histone posttranslational modifications (HPTMs) are crucial epigenetic mechanisms regulating various biological events. Different types of HPTMs characterize and shape functional chromatin states alone or in combination, and dedicated effector proteins selectively recognize these…
#872 引用
CIRCULATION RESEARCH · 2022 · Vol.131 (5) · p.456-472
Cai, WQ; Xu, DC; Zeng, C; Liao, F; et al.
Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as a post-translational histone modification that robustly indicates active promoters. However, the role of Kc…
#969 引用
PROTEOMICS · 2018 · Vol.18 (15)
Huang, H; Wang, DL; Zhao, YM
Lysine crotonylation (Kcr) is a recently identified post-translational modification (PTM) that is regulated by an acetyltransferase, p300. The p300-catalyzed histone Kcr is able to stimulate transcription to a greater degree than the well-studied histone lysine acetylation (Kac).…
#1068 引用
SCIENTIFIC REPORTS · 2017 · Vol.7
Sun, HJ; Liu, XW; Li, FF; Li, W; et al.
Histone crotonylation is a new lysine acylation type of post-translational modification (PTM) enriched at active gene promoters and potential enhancers in yeast and mammalian cells. However, lysine crotonylation in nonhistone proteins and plant cells has not yet been studied. In …