Top Cited Papers (WoS Core)
琥珀酰化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#1692 引用
CELL METABOLISM · 2014 · Vol.19 (4) · p.605-617
Tan, MJ; Peng, C; Anderson, KA; Chhoy, P; et al.
We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (K-glu). This protein modification was detected by immunoblot and mass spectrometry (MS), and then comprehensively validated by chemical and…
#2296 引用
JOURNAL OF THEORETICAL BIOLOGY · 2016 · Vol.394 · p.223-230
Jia, JH; Liu, Z; Xiao, X; Liu, BX; et al.
Being one type of post-translational modifications (PTMs), protein lysine succinylation is important in regulating varieties of biological processes. It is also involved with some diseases, however. Consequently, from the angles of both basic research and drug development, we are…
#3222 引用
CELL METABOLISM · 2017 · Vol.25 (4) · p.823-+
Wagner, GR; Bhatt, DP; O'Connell, TM; Thompson, JW; et al.
The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergo intramolecular catalysis to form reactive intermediates that non-enzymati…
#4194 引用
JOURNAL OF GENETICS AND GENOMICS · 2017 · Vol.44 (5) · p.243-250
Xu, HD; Zhou, JQ; Lin, SF; Deng, WK; et al.
Post-translational modifications (PTMs) occurring at protein lysine residues, or protein lysine modifications (PLMs), play critical roles in regulating biological processes. Due to the explosive expansion of the amount of PLM substrates and the discovery of novel PLM types, here …
#5175 引用
ONCOTARGET · 2016 · Vol.7 (23) · p.34558-34570
Jia, JH; Liu, Z; Xiao, X; Liu, BX; et al.
Carbonylation is a posttranslational modification (PTM or PTLM), where a carbonyl group is added to lysine (K), proline (P), arginine (R), and threonine (T) residue of a protein molecule. Carbonylation plays an important role in orchestrating various biological processes but it i…
#6151 引用
MOLECULAR & CELLULAR PROTEOMICS · 2015 · Vol.14 (11) · p.3056-3071
Colak, G; Pougovkina, O; Dai, LZ; Tan, MJ; et al.
The protein substrates of sirtuin 5-regulated lysine malonylation (Kmal) remain unknown, hindering its functional analysis. In this study, we carried out proteomic screening, which identified 4042 Kmal sites on 1426 proteins in mouse liver and 4943 Kmal sites on 1822 proteins in …
#7147 引用
CELL REPORTS · 2018 · Vol.22 (6) · p.1365-1373
Kurmi, K; Hitosugi, S; Wiese, EK; Boakye-Agyeman, F; et al.
Lysine succinylation was recently identified as a post-translational modification in cells. However, the molecular mechanism underlying lysine succinylation remains unclear. Here, we show that carnitine palmitoyltransferase 1A (CPT1A) has lysine succinyltransferase (LSTase) activ…
#8146 引用
EMBO REPORTS · 2021 · Vol.22 (2)
Yang, G; Yuan, Y; Yuan, HF; Wang, JP; et al.
Lysine succinylation (Ksucc) is an evolutionarily conserved and widespread post-translational modification. Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. However, the role of HAT1 in …
#9122 引用
MOLECULAR & CELLULAR PROTEOMICS · 2015 · Vol.14 (1) · p.227-236
Du, YP; Cai, TX; Li, TT; Xue, P; et al.
Protein lysine malonylation, a newly identified protein post-translational modification (PTM), has been proved to be evolutionarily conserved and is present in both eukaryotic and prokaryotic cells. However, its potential roles associated with human diseases remain largely unknow…
#10116 引用
JOURNAL OF PROTEOME RESEARCH · 2016 · Vol.15 (3) · p.879-890
He, DL; Wang, Q; Li, M; Damaris, RN; et al.
Regulation of rice seed germination has been shown to mainly occur at post-transcriptional levels, of which the changes on proteome status is a major one. Lysine acetylation and succinylation are two prevalent protein post-translational modifications (PTMs) involved in multiple b…