Top Cited Papers (WoS Core)
乙酰化 Top 10 高被引论文
按 WoS Core Collection 总被引次数排序，覆盖方法学、机制研究与疾病转化。每条论文提供 DOI 直链 + 摘要前 280 字 + 前 4 位作者。
#11510 引用
CELL · 2011 · Vol.146 (6) · p.1015-1027
Tan, MJ; Luo, H; Lee, S; Jin, FL; et al.
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved hist…
#21185 引用
SCIENCE · 2011 · Vol.334 (6057) · p.806-809
Du, JT; Zhou, YY; Su, XY; Yu, JJ; et al.
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that regulate important biological processes. Mammals have seven sirtuins, Sirt1 to Sirt7. Four of them (Sirt4 to Sirt7) have no detectable or very weak deacetyl…
#3692 引用
CELL METABOLISM · 2014 · Vol.19 (4) · p.605-617
Tan, MJ; Peng, C; Anderson, KA; Chhoy, P; et al.
We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine glutarylation (K-glu). This protein modification was detected by immunoblot and mass spectrometry (MS), and then comprehensively validated by chemical and…
#4644 引用
MOLECULAR & CELLULAR PROTEOMICS · 2011 · Vol.10 (12)
Peng, C; Lu, ZK; Xie, ZY; Cheng, ZY; et al.
Protein post-translational modifications (PTMs) at the lysine residue, such as lysine methylation, acetylation, and ubiquitination, are diverse, abundant, and dynamic. They play a key role in the regulation of diverse cellular physiology. Here we report discovery of a new type of…
#5508 引用
NATURE METABOLISM · 2023 · Vol.5 (1) · p.61-+
Yang, ZJ; Yan, C; Ma, JQ; Peng, PP; et al.
Enhanced glycolysis and accumulation of lactate is a common feature in various types of cancer. Intracellular lactate drives a recently described type of posttranslational modification, lysine lactylation (Kla), on core histones. However, the impact of lactylation on biological p…
#6505 引用
MOLECULAR & CELLULAR PROTEOMICS · 2012 · Vol.11 (5) · p.100-107
Xie, ZY; Dai, JBA; Dai, LZ; Tan, MJ; et al.
Histone protein post-translational modifications (PTMs) are significant for gene expression and DNA repair. Here we report the identification and validation of a new type of PTM in histones, lysine succinylation. The identified lysine succinylated histone peptides were verified b…
#7391 引用
PHARMACOLOGICAL REVIEWS · 2022 · Vol.74 (3) · p.506-551
Dambrova, M; Makrecka-Kuka, M; Kuka, J; Vilskersts, R; et al.
Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy metabolism pathways. They have historically been used as important diagnostic markers for inborn errors of fatty acid oxidation and are being intensively studied as markers of energy metab…
#8268 引用
ELIFE · 2014 · Vol.3
Bao, XC; Wang, Y; Li, X; Li, XM; et al.
Posttranslational modifications (PTMs) play a crucial role in a wide range of biological processes. Lysine crotonylation (Kcr) is a newly discovered histone PTM that is enriched at active gene promoters and potential enhancers in mammalian cell genomes. However, the cellular enzy…
#9239 引用
MOLECULAR ASPECTS OF MEDICINE · 2022 · Vol.86
Pan, S; Chen, R
Protein post-translational modifications (PTMs) profoundly influence protein functions and play crucial roles in essentially all cell biological processes. The diverse realm of PTMs and their crosstalk is linked to many critical signaling events involved in neoplastic transformat…
#10233 引用
EMBO REPORTS · 2023 · Vol.24 (5)
Jin, J; Bai, L; Wang, DY; Ding, W; et al.
Lysine lactylation (Kla) is a recently discovered histone mark derived from metabolic lactate. The NAD(+)-dependent deacetylase SIRT3, which can also catalyze removal of the lactyl moiety from lysine, is expressed at low levels in hepatocellular carcinoma (HCC) and has been sugge…